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KMID : 0613820110210081199
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Journal of Life Science
2011 Volume.21 No. 8 p.1199 ~ p.1203
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In vitro Activities of Polycalcium, a Mixture of Polycan and Calcium Lactate-Gluconate, on Osteoclasts and Osteoblasts
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Choi Jae-Suk
Kim Joo-Wan
Kim Ki-Young
Moon Seung-Bae
Ha Yu-Mi
Ku Sae-Kwang
Cho Kwang-Keun
Choi In-Soon
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Abstract
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The present study evaluated the beneficial effects of polycalcium (a mixture of Polycan and calcium lactate-gluconate 1:9 [g/g]) on osteoporosis using in vitro assays. Cell proliferation and alkaline phosphatase activities of osteoblasts (human primary osteoblasts) and osteoclast differentiation of RAW264.7 cells (murine osteoclast progenitor cells) treated with different concentrations of polycalcium for various periods were assessed. Osteoblast proliferation was stimulated and prevented RANKL-induced osteoclast differentiation of RAW264.7 cells. These results support the development of ideal anti-osteoporotic agents, such as polycalcium, that exhibit properties that accelerate bone formation and inhibit bone resorption.
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KEYWORD
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Polycalcium, polycan, osteoclasts, osteoblasts
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